Electrophysiological Biomarkers in ADHD

In Zusammenarbeit mit  Prof. Andreas Hierlemann, ETHZ

Duration
2023-2027 on going

We propose to combine recent technological advances in human stem cell biology with cutting-edge high-density microelectrode array (HD-MEA) technology. Human induced pluripotent stem cell (iPSC)-derived neurons retain the unique genetic signatures of their donors and enable the study of complex genetic diseases, such as ADHD. HD-MEA technology provides access to network activity at high spatiotemporal resolution, ranging from subcellular compartments through individual neurons to entire networks. Combining human iPSC technology with HD-MEA recordings will provide a high-performance phenotypic screening platform, which helps to facilitate the assessment of medication, supports the development of specific and personalized treatment strategies, and accelerates drug discovery.

Project link: https://www.sfa-phrt.ch/electrophysiological-biomarker-discovery-and-treatment-response-prediction-for-attention-deficit-hyperactivity-disorder-adhd/

Contact Person
Prof. Dr. Edna Grünblatt
Department of Child and Adolescent Psychiatry and Psychotherapy,
Psychiatric Hospital University of Zürich
edna.gruenblatt@kjpd.uzh.ch

Prof. Dr. Andreas Hierlemann
BioEngineering Laboratory, ETHZ
andreas.hierlemann@bsse.ethz.ch