Single cell RNA sequencing in ADHD

Collaboration Dr. Farhan & Dr Thomas, McGill

Duration
2023-2024 on going

ADHD is a prevalent neurodevelopmental bmental disorder. It is a complex condition influenced by both heredity and environmental factors. The Wnt signalling pathway, which plays a role in neurodevelopment and cognitive processes, has been identified as one of the routes associated with ADHD. Induced pluripotent stem cells (iPSCs) have been a valuable tool in studying neuropsychiatric disorders due to limitations in animal models and neuroimaging studies in fully replicating human clinical conditions and polygenic profiles, as well as investigating molecular mechanisms in living functional cells from the human Central Nervous System. We have been studying proteome variations related to Wnt signalling and variances in neural stem cell growth. This initiative aims to analyse intricate single-cell RNA sequencing data from neural stem cells (NSCs) and forebrain cortical neurons (FCNs) differentiated from ADHD ptients and controls iPSC. We believe these data will clarify our prior discoveries and provide insight into differentially expressed genes (DEGs) and other pathways that could be potentially related to ADHD.

Project link: https://www.mcgill.ca/neuro/article/research/acar-announces-recipients-2022-mcgill-znz-neuroscience-partnership-grant

Contact
Prof. Dr. Edna Grünblatt
Department of Child and Adolescent Psychiatry and Psychotherapy,
Psychiatric Hospital University of Zürich
edna.gruenblatt@kjpd.uzh.ch

Collaboration
Dr. Rhalena Thomas
The Neuro, McGill
rhalena.thomas@mcgill.ca