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Collaboration: Prof. Landolt, Children’s Hospital Zurich
Duration: 2019-2023 on going
Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood. Primary failure of neural tube closure at the caudal neuropore in the embryonic period results in exposure of the developing spinal cord to the uterine environment. Without protective tissue coverage, secondary destruction of the exposed neural tissue by trauma or amniotic fluid may occur throughout gestation. In order to protect the spinal cord from this secondary destruction, a fetal surgical repair can be performed between gestational weeks 20 and 26.
From a psychological point of view fetal repair of MMC constitutes a highly stressful event both for the mother and the fetus. To date, however, stress of mothers and children in case of prenatal surgery for MMC repair has never been studied. It is therefore unclear, if and to what extend the procedure and its consequences are associated with stress, and if there are short- or longer-term consequences.
The aims of this study are threefold:
Project link: https://www.psychologie.uzh.ch/de/bereiche/hea/gespsy/forschung/Fetal-Epigenetic-Study.html
Prof. Dr. Edna Grünblatt
Psychiatrische Universitätsklinik Zürich
Kinder- und Jugendpsychiatrie und Psychotherapie
edna.gruenblatt@kjpd.uzh.ch
Prof. Dr. Markus Landolt
Prof. für Gesundheitspsychologie des Kindes- und Jugendalters, UZH
markus.landolt@kispi.uzh.ch